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Intern-S2-Preview-397B GPU Requirements: VRAM & Cheapest GPU

Intern-S2-Preview-397B has about 403B parameters. See exactly how much GPU memory it needs at FP16, INT8, and INT4, and the cheapest GPU to run it, with live hourly pricing from 5+ data center partners.

403BParameters
220 GBMin VRAM
$3.44/hrCheapest
< 2 minDeploy
internlm/Intern-S2-Preview-397B
VIEW ON HUGGINGFACE ↗
403B paramsimage-text-to-textintern_s2_preview62 downloads50 likesupdated Jul 20, 2026

To run Intern-S2-Preview-397B for inference at FP16, you need roughly 879 GB of VRAM. The cheapest fit on Spheron is 8x H200 141GB at about $14.16/hr. Quantize to INT4 to run it on a smaller, cheaper GPU.

GB VRAM REQUIRED
FP16INFERENCEBATCH 1CTX 4k

Estimated peak VRAM including weights, activations, and KV cache. Add 10% headroom for production traffic.

RANKCONFIGURATIONPER GPUTOTAL $/HR
  • 01
    8× H200 141GBCHEAPEST
    Hopper · HBM3e
    $1.77/hr$14.16/hr
  • 02
    4× B300 288GB
    Blackwell Ultra · HBM3e
    $5.81/hr$23.24/hr
  • 03
    8× B200 192GB
    Blackwell · HBM3e
    $5.34/hr$42.72/hr

Live pricing aggregated from 5+ data center partners. Per-minute billing, no commitments.

VRAM required to run Intern-S2-Preview-397B

Estimated peak VRAM at context length 4,096 and batch size 1, including weights, activations, and KV cache. Quantizing to INT8 (Q8) or INT4 (Q4) cuts memory roughly in half and in quarter.

PrecisionInferenceLoRA fine-tuneFull fine-tune
FP16879 GB1319 GB3518 GB
INT8440 GB660 GB1759 GB
INT4220 GB330 GB879 GB

Cheapest GPU to run Intern-S2-Preview-397B by precision

FP16
VRAM required879GB

Full precision. Best quality, highest memory.

Cheapest GPU
8x H200 141GB
Hopper · HBM3e
$14.16/hr · $1.77/hr/gpu
8x H200 141GB on Spheron
INT8
VRAM required440GB

8-bit quantized. ~2x smaller, minimal quality loss.

Cheapest GPU
8x RTX PRO 6000 96GB
Blackwell · GDDR7
$6.88/hr · $0.86/hr/gpu
8x RTX PRO 6000 96GB on Spheron
INT4
VRAM required220GB

4-bit quantized. ~4x smaller, runs on smaller GPUs.

Cheapest GPU
4x RTX PRO 6000 96GB
Blackwell · GDDR7
$3.44/hr · $0.86/hr/gpu
4x RTX PRO 6000 96GB on Spheron

Inference vs fine-tuning Intern-S2-Preview-397B

InferenceWeights + KV cache
LoRA fine-tune~1.5×+ low-rank adapter
Full fine-tune~4×+ gradients + optimizer state

Inference only holds the model weights plus a KV cache, so it is the cheapest setup. LoRA fine-tuning adds a small adapter and roughly 50% more memory. Full fine-tuning holds gradients and optimizer state on top of the weights, which is about 4x the inference footprint, so it often needs multiple GPUs even when inference fits on one. For Intern-S2-Preview-397B, an on-demand H200 141GB instance covers inference and LoRA, while a full fine-tune needs several times that memory and often spans multiple GPUs. Check the live GPU pricing for current rates.

Similar models

Compare GPU requirements for models in the same class.

FAQ / 05

Intern-S2-Preview-397B GPU questions

Intern-S2-Preview-397B has about 403B parameters. At FP16 it needs roughly 879 GB of VRAM for inference, including weights, activations, and KV cache. Quantized to INT4 that drops to around 220 GB. Leave about 10% headroom for production traffic.

For FP16 inference, the cheapest fit on Spheron is 8x H200 141GB at about $14.16/hr. If you quantize to INT4, 4x RTX PRO 6000 96GB at about $3.44/hr runs it for less. Pricing is aggregated live from 5+ data center partners with per-minute billing.

LoRA fine-tuning adds roughly 50% on top of inference memory, so it usually fits the same class of GPU. Full fine-tuning holds gradients and optimizer state and needs about 4x the inference VRAM, which often means multiple GPUs for Intern-S2-Preview-397B. The VRAM matrix above shows the exact estimate for each setup.

We read the parameter count directly from the model's safetensors metadata on HuggingFace, then estimate peak VRAM from weights, activations, KV cache, and framework overhead at your chosen precision. The estimate lands within about 15% of real-world use for most transformer models.

Quantized to INT4, Intern-S2-Preview-397B needs about 220 GB of VRAM, so it is too large for a single 24 GB RTX 4090 and needs a bigger card or multiple GPUs. At FP16 it needs roughly 879 GB, which usually means a data center GPU. The precision picks above list the cheapest GPU that fits each setup.